{"id":15,"date":"2015-04-19T03:23:50","date_gmt":"2015-04-19T03:23:50","guid":{"rendered":"https:\/\/rougechem.org\/?page_id=15"},"modified":"2025-11-05T14:04:23","modified_gmt":"2025-11-05T14:04:23","slug":"publications","status":"publish","type":"page","link":"https:\/\/rougechem.org\/?page_id=15","title":{"rendered":"Publications"},"content":{"rendered":"\n

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Pal, S.; Singla, D.; Canete, R. C.; Darkwah, J. B.; Cannata, J. N.; Hunte, M. L.; Penales, I. B.; Szczepanek, S. M. Ducong\u00e9, F.; Smilowitz, H. M.; Rouge, J. L. A Virus Inspired mRNA Delivery Vehicle Enabled by a Multilayered Nucleic Acid Nanocapsule<\/strong><\/a>, ACS Nano<\/strong><\/em>, 2025<\/strong>, accepted.<\/em><\/p>\n\n\n

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Hiniduma, K.;  De Silva, P. I. T.; Canete, R.;  Vora, P.; Gunathillaka, H.;  Clement, O.; Shawky, S. M.; Rouge, J. L.; Mosa, I. M.,<\/sup> Steffens, D.C.;  Manning, K.; Breno. D.; Rusling, J. F. ECL-CRISPR Array for Multiplexed Detection of miRNAs<\/strong><\/a>, Biosensors and Bioelectronics<\/strong><\/em>, 2025<\/strong>, 289, 117855.<\/p>\n\n\n\n

Gorecki, J.; de la Fuente, I. F.; Corrigan, P. M.; Pal, S.; Cannata, J. N.; Rouge, J. L. Enhancing the membrane destabilization of enzymatically released DNA Surfactant Conjugates for improved endosomal escape and gene expression<\/strong>, Chemrxiv preprint, 2025<\/em>.<\/p>\n\n\n\n

Gudipati, S.; Sawant, S. S.; Canete, R. C.; Corrigan, P. M.; Rouge, J. L. An RT-PCR Based Method for Determining Aptamer-Protein Interactions at Nanoparticle Surfaces<\/strong><\/a>, ChemNanoMat<\/strong><\/em>, 2025<\/strong>, 2500301.<\/p>\n\n\n

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Pal, S.; Cannata, J. N., Rouge, J. L. Nucleic Acid Nanocapsules as a New Platform to Deliver Therapeutic Nucleic Acids for Gene Regulation<\/a><\/strong>, Acc. Chem. Res<\/strong><\/em>., 2025<\/strong>, <\/em>58, 13, 1951-1962.<\/p>\n\n\n

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De Silva, P.I.T.; Hiniduma, K.; Canete, R.; Bhalerao, K.S.; Shawky, S.M.; Gunathilaka, H.; Rouge, J.L.; Mosa, I.M.; Steffens, D.C.; Manning, K.; Diniz, B.S.; Rusling, J. F. Multiplexed CRISPR Assay for Amplification-Free Detection of miRNAs<\/strong><\/a>. Biosensors<\/em><\/strong>, 2025<\/strong>, 15, 346<\/p>\n\n\n\n

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de la Fuente, I. F.; Sawant, S. S.; Kho, K. W.; Sarangi, N.; Pal, S.; Liang, L. H.; Keyes, T. E.; Rouge, J. L. The effect of surfactant tail length on the intracellular delivery of DNA-surfactant conjugates<\/a><\/strong>, ACS Appl. Mater. Interfaces <\/strong><\/em>2024<\/strong>, 16, 43400-43415 .<\/em> <\/strong><\/p>\n\n\n

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Pal, S.; de la Fuente, I. F.; Sawant, S. S.; Cannata, J.; He, W.; Rouge, J. L. Cellular Uptake Mechanism of Nucleic Acid Nanocapsules and their DNA-Surfactant Building Blocks<\/strong><\/a>, Bioconjugate Chem<\/em><\/strong>., 2023<\/strong>, 34, 6, 1004\u20131013. <\/p>\n\n\n

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Sawant, S. S.; Gudipati, S.; Veczko, S.; Rouge, J. L. Controlled Release of a Dual Zinc-Sensing and Gene Regulating Small Molecule from DNA Micelles<\/strong><\/a>, ChemBioChem<\/em><\/strong>, 2023<\/strong>, 24, 11 e202300189.<\/p>\n\n\n\n

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Rouge, J. L. RNA and Nanocarriers: Next generation drug and delivery platform take center stage<\/a><\/strong>, Trends Biotechnol<\/em>, 2023<\/strong>, 41, 281-282.<\/p>\n\n\n

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Santiana, J. J.; Sawant, S. S.; Gomez, N., Rouge, J. L. Multi-Layered Stimuli Responsive DNA Micelles for the Stepwise Controlled Release of Small Molecules<\/a><\/strong>, J. Mater. Chem. B<\/strong><\/em>. 2022<\/strong>, <\/em>10, 7518-7526.* Featured in the themed issue “2022 Emerging Investigators<\/em>.<\/strong>” <\/p>\n\n\n

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Gavitt, T. D.; Hartmann, A. K.; Mara, A. B.; Szczepanek, S. M.; Rouge, J. L. A GATA3-Targeting Nucleic Acid Nanocapsule for in vivo gene regulation in Asthma<\/strong><\/a>, ACS Nano<\/em><\/strong>, 2021<\/strong>, 15, 7, 11192-11201.<\/p>\n\n\n

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Tolentino, M. Q.; Rouge, J. L. A Thermoresponsive Crosslinker for Reversible Micelle Stabilization<\/a><\/strong>, Materials Advances<\/em>, 2021<\/strong>, 2, 2267-2271. <\/p>\n\n\n

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de la Fuente, I. F.; Tolentino, M. Q.; Sawant, S. Corrigan, P. M.; Rouge, J. L. Viral Mimicry as a Design Template for Nucleic Acid Nanocarriers<\/a><\/strong>, Frontiers in Chemistry: Rising stars<\/strong><\/em>, 2021<\/strong>, Volume 9, <\/em>Article 613209.<\/em><\/p>\n\n\n

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Arifuzzaman, M.; Hartmann, A. K.; Rouge, J. L. Tracking nucleic acid nanocapsule assembly, cellular uptake and disassembly using a fluorescently labeled surfactant<\/a><\/strong>, <\/em> RSC Advances<\/strong><\/em>, 2020<\/strong>, 10, 42349 – 42353.<\/p>\n\n\n

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Tolentino, M. Q.; Hartmann, A. K.; Loe, D. T.; Rouge, J. L. Controlled Release of Small Molecules and Proteins from DNA-Surfactant Stabilized Metal Organic Frameworks<\/a><\/strong>,\u00a0\u00a0J. Mater. Chem. B<\/em>., 2020, <\/strong>8, 5627-5635.<\/p>\n

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Hartmann, A. K.; Gudipati, S.; Pettenuzzo, A.; Ronconi, L.; Rouge, J. L. Chimeric siRNA-DNA surfactants for the enhanced delivery and sustained cytotoxicity of gold metallodrugs<\/strong><\/a>, accepted<\/em>, Bioconjugate Chemistry<\/em>, 2020, <\/strong>31, 4, 1063-1069. Highlighted artwork by journal.<\/p>\n

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Shen, Z.; Loe, D. T.; Fisher, A.; Kroger, M.; Rouge, J. L.; Li, Y. Polymer Stiffness Governs Template mediated Self-Assembly of Liposome-Like Nanoparticles: Simulation, Theory and Experiment<\/strong><\/a>, Nanoscale<\/strong><\/em>,\u00a02019<\/strong>,<\/em>\u00a011, 20179-20193.<\/p>\n

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Gudipati, S.; Zhang, K.; Rouge, J. L. Towards Self-Transfecting Nucleic Acid Nanostructures for Gene Regulation<\/strong><\/a>, Trends Biotechnol<\/em><\/strong>., 2019<\/strong>, 37, 983-994. Featured on front cover of journal.<\/em><\/p>\n

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Hartmann, A. K.; Cairns-Gibson, D. F.; Santiana, J. J.; Tolentino, M.; Barber*, H. M.; Rouge, J. L. Enzymatically ligated DNA-surfactants: Unmasking Hydrophobically Modified DNA for Intracellular Gene Regulation<\/strong><\/a>,\u00a0ChemBioChem**<\/strong><\/em>, 2018<\/strong>, 19, 1734-1739. **Selected as Cover Art for Journal, bottom left.\u00a0<\/em><\/p>\n

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Mazrui, N. M.; King\u2019ondu, C. K.;\u00a0Awino, J. K.; Thota, S.; Zhao, J.; Rouge, J. L.; Mason, R. P.\u00a0<\/em>The Precipitation, Growth and Stability of \u03b2-HgS\u00a0Nanoparticles Formed in Presence of Marine Dissolved Organic Matter<\/strong><\/a>,\u00a0Environ. Sci. <\/strong><\/em>Process. Impact<\/em><\/strong>,\u00a02018, <\/strong>20, 642-656.<\/p>\n

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Santiana, J. J.; Sui, B.; Gomez*, N.; Rouge, J. L.\u00a0Programmable Peptide-Crosslinked Nucleic Acid Nanocapsules as a Modular Platform for Enzyme Specific Cargo Release<\/strong><\/a>, Bioconjugate Chem<\/em>.\u00a0<\/strong>2017,\u00a0<\/strong>28, 2910-2914.<\/p>\n

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Awino, J. K.; Gudipati, S.; Hartmann, A. K.; Santiana, J. J.; Cairns-Gibson*, D. F.; Gomez*, N.; Rouge, J. L.\u00a0 \u00a0 \u00a0\u00a0Nucleic Acid Nanocapsules for Enzyme-Triggered Drug Release<\/a>,<\/strong>\u00a0\u00a0J. Am. Chem. Soc.<\/em> 2017<\/strong>, 139, 6278-6281.<\/p>\n

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Shen, Z.; Loe, D. T.; Awino, J. K.; Kroger, M.; Rouge, J. L.; Li, Y. Self-Assembly of Core-Polyethylene Glycol-Lipid Shell (CPLS) Nanoparticles and the Potential as Drug Delivery Vehicles<\/a><\/strong>, Nanoscale<\/em><\/strong>, 2016<\/strong>, 8, 14821-14835.<\/p>\n

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Undergraduate researchers indicated by *<\/p>\n

Prior to UConn<\/em><\/strong><\/p>\n

Seo, S. E.; Wang, M. X.; Shade, C. M.; Rouge, J. L<\/strong>.; Brown, K. A.; Mirkin, C.A. Modulating the Bond Strength of DNA-Nanoparticle Superlattices<\/a><\/strong>. ACS Nano<\/em><\/strong>, 2016, <\/strong>10, 1771-1779.<\/p>\n

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Rouge, J. L<\/strong>.; Sita, T. L.; Hao, L.; Kouri, F. M.; Briley, W. E.; Stegh, A. H.; Mirkin, C. A. Ribozyme-Spherical Nucleic Acids<\/a><\/strong>, J. Am. Chem. Soc.<\/em> 2015<\/strong>,\u00a0137, 10528-10531.<\/p>\n

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Shade, C. M.; Kennedy, R. D.; Rouge, J. L<\/strong>.; Rosen, M. S.; Wang, M. X.; Seo, S. E.; Clingerman, D. J.; Mirkin, C. A. Duplex-Selective Ruthenium Intercalators<\/a><\/strong>, Chem. Eur. J. <\/strong><\/em>2015<\/strong>, <\/em>21, 1-6.<\/p>\n

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Rouge, J. L<\/strong>.; Hao, L.; Wu, X. A.; Briley, W. E.; Mirkin, C. A. Spherical Nucleic Acids as a Divergent platform for assembling RNA-Nanoparticle constructs through Enzymatic Ligation*<\/a>*<\/strong>. ACS Nano<\/em><\/strong>, 2014<\/strong>, 8, 8837-8843.<\/p>\n

**Highlighted by Chemical and Engineering News, Sept. 2014<\/strong><\/em><\/p>\n

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Calabrese, C. M.; Merkel, T. J.; Briley, W. E.; Randeria, P. S.; Narayan, S. P.; Rouge, J. L<\/strong>.; Walker, D. A.; Scott, A. W.; Mirkin, C. A. Biocompatible Infinite Coordination Polymer Nanoparticle \u2013Nucleic Acid Conjugates For Antisense Gene Regulation<\/a><\/strong>. Angew. Chem. Int. Ed<\/em><\/strong>. 2014<\/strong>, 54, 476-480.<\/p>\n

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Rouge, J. L<\/strong>.; Eaton, B. E.; Feldheim, D. L. Biomolecules in the Synthesis and Assembly of Materials for Energy Applications<\/a><\/strong>., Energy Environ. Sci<\/em>.,<\/strong> 2011<\/strong>, 4, 398 \u2013 402.<\/p>\n

Rouge, J, L<\/strong>.; Ackerson, C. J.; Feldheim, D. L.; Eaton, B. E. Cooperativity between two selected RNA Pdases in the synthesis of crystalline Pd Nanoparticles<\/a><\/strong>., J. Mater. Chem<\/em><\/strong>. 2010<\/strong>, 20, 8394 \u2013 8398.<\/p>\n

Baker, T. A.; Rouge, J. L<\/strong>.; Nesbitt, D. J. Single molecule studies of quantum dot fluorescence intermittency: evidence for both dark and light-assisted blinking dynamics<\/a><\/strong>. Mol. Phys<\/em>.<\/strong>, 2009<\/strong>, 107, 1867-1878.<\/p>\n

Dooley, C. J.;\u00a0 Rouge, J<\/strong>.; Ma, N.; Invernale, M.; Kelley, S. O. Nucleotide-stabilized cadmium sulfide nanoparticles<\/a>**.<\/strong>, J. Mater. Chem<\/strong>.<\/em>, 2007<\/strong>, 17, 1687-1691<\/p>\n

* *Hot article in RSC Publishing<\/strong><\/em><\/p>\n

Mahon Jr., K. P; Roy, M. D.; Carreon, J. R.; Prestwich, E. G.; Rouge, J. L<\/strong>.; Shin, S.; Kelley, S. O. Tunable DNA cleavage by intercalating peptidoconjugates<\/a><\/strong>. ChemBioChem<\/em>,<\/strong> 2005<\/strong>, 7, 766-773.<\/p>\n

Book Chapters<\/strong><\/p>\n

Cannata, J. N.; Rouge, J. L (2024<\/strong>) Callmann, C. E. (ed.) Enzymatically Ligated Nucleic Acid Nanocapsules for the Delivery of Therapeutic Nucleic Acids and Small Molecule Drugs<\/strong>, Biomedical Nanotechnology, Springer, accepted<\/em><\/p>\n

Santiana, J. J.; Gudipati, S.; Hartmann, A. Rouge, J. L. “Hybrid Nucleic Acid Nanocapsules for Targeted, Enzyme-Specific Drug Delivery and Intracellular Gene Regulation<\/strong>,” Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity<\/em>, 2018<\/strong>.<\/p>\n

Patents\u00a0<\/strong><\/p>\n

Rouge, J<\/strong>. L<\/strong>., Suman, P.; Singla, D. \u201cNucleic Acid Nanocapsules for drug delivery\u201d U.S. Application No. 63\/521,369 Filed June 16, 2023<\/strong><\/p>\n

Rouge, J. L<\/strong>.; Awino, J. K. “Multifunctional enzyme responsive Nucleic Acid Nanocapsules as Drug Delivery Agents<\/strong><\/a>.” US Non-provisional and PCT Patent Applications filed June 2018. Awarded Sept 2020.<\/strong><\/p>\n

Rouge, J. L<\/strong>. \u00a0“A Universal Enzyme Responsive Linker for Assembling Ligands on DNA Functionalized Nanomaterials<\/strong>” US Non-Provisional Patent Application filed March 2018. Awarded Feb 2019<\/strong>.<\/p>\n

Mirkin, C. A.; Rouge, J. L<\/strong>.; Shade, C. M.; Seo, S. E.; Wang, M. X. “Duplex-Selective Ruthenium-based DNA Intercalators and their application as DNA Staining Agents<\/a><\/strong>,” Filed 2015.\u00a0US 20170082614 A1 (2018)<\/strong>.<\/p>\n

Mirkin, C. A.; Rouge, J. L.<\/strong>; Scott, A. W. “Modified silica shell particles, and methods of making and using the same<\/a><\/strong>,” 2015<\/strong>, WO Patent 2015031580-A1, US 2016\/0361266 A1.<\/strong><\/p>","protected":false},"excerpt":{"rendered":"

Pal, S.; Singla, D.; Canete, R. C.; Darkwah, J. B.; Cannata, J.…<\/p>\n

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