Pal, S.; Singla, D.; Cannata, J. N.; Duconge, F.; Smilowitz, H. M.; Rouge, J. L. Room Temperature Stabilization and Enzyme Gated Expression of mRNA Enabled by a Multilayered Nucleic Acid Nanocapsule, 2024, submitted.

de la Fuente, I. F.; Sawant, S. S.; Kho, K. W.; Sarangi, N.; Pal, S.; Liang, L. H.; Keyes, T. E.; Rouge, J. L. The effect of surfactant tail length on the intracellular delivery of DNA-surfactant conjugates, 2023,under revision.

Pal, S.; de la Fuente, I. F.; Sawant, S. S.; Cannata, J.; He, W.; Rouge, J. L. Cellular Uptake Mechanism of Nucleic Acid Nanocapsules and their DNA-Surfactant Building Blocks, Bioconjugate Chem., 2023, 34, 6, 1004–1013.

Sawant, S. S.; Gudipati, S.; Veczko, S.; Rouge, J. L. Controlled Release of a Dual Zinc-Sensing and Gene Regulating Small Molecule from DNA Micelles, ChemBioChem, 2023, accepted.

Rouge, J. L. RNA and Nanocarriers: Next generation drug and delivery platform take center stage, Trends Biotechnol, 2023, in press.

Santiana, J. J.; Sawant, S. S.; Gomez, N., Rouge, J. L. Multi-Layered Stimuli Responsive DNA Micelles for the Stepwise Controlled Release of Small Molecules, J. Mater. Chem. B. 2022, 10, 7518-7526.* Featured in the themed issue “2022 Emerging Investigators.

Gavitt, T. D.; Hartmann, A. K.; Mara, A. B.; Szczepanek, S. M.; Rouge, J. L. A GATA3-Targeting Nucleic Acid Nanocapsule for in vivo gene regulation in Asthma, ACS Nano, 2021, 15, 7, 11192-11201.

Tolentino, M. Q.; Rouge, J. L. A Thermoresponsive Crosslinker for Reversible Micelle Stabilization, Materials Advances, 2021, 2, 2267-2271.

de la Fuente, I. F.; Tolentino, M. Q.; Sawant, S. Corrigan, P. M.; Rouge, J. L. Viral Mimicry as a Design Template for Nucleic Acid Nanocarriers, Frontiers in Chemistry: Rising stars, 2021, Volume 9, Article 613209.

Arifuzzaman, M.; Hartmann, A. K.; Rouge, J. L. Tracking nucleic acid nanocapsule assembly, cellular uptake and disassembly using a fluorescently labeled surfactant, RSC Advances, 2020, 10, 42349 – 42353.

Tolentino, M. Q.; Hartmann, A. K.; Loe, D. T.; Rouge, J. L. Controlled Release of Small Molecules and Proteins from DNA-Surfactant Stabilized Metal Organic Frameworks,  J. Mater. Chem. B., 2020, 8, 5627-5635.

Hartmann, A. K.; Gudipati, S.; Pettenuzzo, A.; Ronconi, L.; Rouge, J. L. Chimeric siRNA-DNA surfactants for the enhanced delivery and sustained cytotoxicity of gold metallodrugs, accepted, Bioconjugate Chemistry, 2020, 31, 4, 1063-1069. Highlighted artwork by journal.

Shen, Z.; Loe, D. T.; Fisher, A.; Kroger, M.; Rouge, J. L.; Li, Y. Polymer Stiffness Governs Template mediated Self-Assembly of Liposome-Like Nanoparticles: Simulation, Theory and Experiment, Nanoscale2019, 11, 20179-20193.

Gudipati, S.; Zhang, K.; Rouge, J. L. Towards Self-Transfecting Nucleic Acid Nanostructures for Gene Regulation, Trends Biotechnol., 2019, 37, 983-994. Featured on front cover of journal.

Hartmann, A. K.; Cairns-Gibson, D. F.; Santiana, J. J.; Tolentino, M.; Barber*, H. M.; Rouge, J. L. Enzymatically ligated DNA-surfactants: Unmasking Hydrophobically Modified DNA for Intracellular Gene RegulationChemBioChem**, 2018, 19, 1734-1739. **Selected as Cover Art for Journal, bottom left. 

Mazrui, N. M.; King’ondu, C. K.; Awino, J. K.; Thota, S.; Zhao, J.; Rouge, J. L.; Mason, R. PThe Precipitation, Growth and Stability of β-HgS Nanoparticles Formed in Presence of Marine Dissolved Organic Matter, Environ. Sci. Process. Impact2018, 20, 642-656.

Santiana, J. J.; Sui, B.; Gomez*, N.; Rouge, J. L. Programmable Peptide-Crosslinked Nucleic Acid Nanocapsules as a Modular Platform for Enzyme Specific Cargo Release, Bioconjugate Chem2017, 28, 2910-2914.


Awino, J. K.; Gudipati, S.; Hartmann, A. K.; Santiana, J. J.; Cairns-Gibson*, D. F.; Gomez*, N.; Rouge, J. L.      Nucleic Acid Nanocapsules for Enzyme-Triggered Drug Release,  J. Am. Chem. Soc. 2017, 139, 6278-6281.

Shen, Z.; Loe, D. T.; Awino, J. K.; Kroger, M.; Rouge, J. L.; Li, Y. Self-Assembly of Core-Polyethylene Glycol-Lipid Shell (CPLS) Nanoparticles and the Potential as Drug Delivery Vehicles, Nanoscale, 2016, 8, 14821-14835.

Undergraduate researchers indicated by *

Prior to UConn

Seo, S. E.; Wang, M. X.; Shade, C. M.; Rouge, J. L.; Brown, K. A.; Mirkin, C.A. Modulating the Bond Strength of DNA-Nanoparticle Superlattices. ACS Nano, 2016, 10, 1771-1779.

Rouge, J. L.; Sita, T. L.; Hao, L.; Kouri, F. M.; Briley, W. E.; Stegh, A. H.; Mirkin, C. A. Ribozyme-Spherical Nucleic Acids, J. Am. Chem. Soc. 2015, 137, 10528-10531.

Shade, C. M.; Kennedy, R. D.; Rouge, J. L.; Rosen, M. S.; Wang, M. X.; Seo, S. E.; Clingerman, D. J.; Mirkin, C. A. Duplex-Selective Ruthenium Intercalators, Chem. Eur. J. 2015, 21, 1-6.

Rouge, J. L.; Hao, L.; Wu, X. A.; Briley, W. E.; Mirkin, C. A. Spherical Nucleic Acids as a Divergent platform for assembling RNA-Nanoparticle constructs through Enzymatic Ligation**. ACS Nano, 2014, 8, 8837-8843.

**Highlighted by Chemical and Engineering News, Sept. 2014

Calabrese, C. M.; Merkel, T. J.; Briley, W. E.; Randeria, P. S.; Narayan, S. P.; Rouge, J. L.; Walker, D. A.; Scott, A. W.; Mirkin, C. A. Biocompatible Infinite Coordination Polymer Nanoparticle –Nucleic Acid Conjugates For Antisense Gene Regulation. Angew. Chem. Int. Ed. 2014, 54, 476-480.

Rouge, J. L.; Eaton, B. E.; Feldheim, D. L. Biomolecules in the Synthesis and Assembly of Materials for Energy Applications., Energy Environ. Sci., 2011, 4, 398 – 402.

Rouge, J, L.; Ackerson, C. J.; Feldheim, D. L.; Eaton, B. E. Cooperativity between two selected RNA Pdases in the synthesis of crystalline Pd Nanoparticles., J. Mater. Chem. 2010, 20, 8394 – 8398.

Baker, T. A.; Rouge, J. L.; Nesbitt, D. J. Single molecule studies of quantum dot fluorescence intermittency: evidence for both dark and light-assisted blinking dynamics. Mol. Phys., 2009, 107, 1867-1878.

Dooley, C. J.;  Rouge, J.; Ma, N.; Invernale, M.; Kelley, S. O. Nucleotide-stabilized cadmium sulfide nanoparticles**., J. Mater. Chem., 2007, 17, 1687-1691

* *Hot article in RSC Publishing

Mahon Jr., K. P; Roy, M. D.; Carreon, J. R.; Prestwich, E. G.; Rouge, J. L.; Shin, S.; Kelley, S. O. Tunable DNA cleavage by intercalating peptidoconjugates. ChemBioChem, 2005, 7, 766-773.

Book Chapters

Cannata, J. N.; Rouge, J. L (2024) Callmann, C. E. (ed.) Enzymatically Ligated Nucleic Acid Nanocapsules for the Delivery of Therapeutic Nucleic Acids and Small Molecule Drugs, Biomedical Nanotechnology, Springer, accepted

Santiana, J. J.; Gudipati, S.; Hartmann, A. Rouge, J. L. “Hybrid Nucleic Acid Nanocapsules for Targeted, Enzyme-Specific Drug Delivery and Intracellular Gene Regulation,” Targeted Nanosystems for Therapeutic Applications: New Concepts, Dynamic Properties, Efficiency, and Toxicity, 2018.


Rouge, J. L., Suman, P.; Singla, D. “Nucleic Acid Nanocapsules for drug delivery” U.S. Application No. 63/521,369 Filed June 16, 2023

Rouge, J. L.; Awino, J. K. “Multifunctional enzyme responsive Nucleic Acid Nanocapsules as Drug Delivery Agents.” US Non-provisional and PCT Patent Applications filed June 2018. Awarded Sept 2020.

Rouge, J. L.  “A Universal Enzyme Responsive Linker for Assembling Ligands on DNA Functionalized Nanomaterials” US Non-Provisional Patent Application filed March 2018. Awarded Feb 2019.

Mirkin, C. A.; Rouge, J. L.; Shade, C. M.; Seo, S. E.; Wang, M. X. “Duplex-Selective Ruthenium-based DNA Intercalators and their application as DNA Staining Agents,” Filed 2015. US 20170082614 A1 (2018).

Mirkin, C. A.; Rouge, J. L.; Scott, A. W. “Modified silica shell particles, and methods of making and using the same,” 2015, WO Patent 2015031580-A1, US 2016/0361266 A1.